Suppression of the normal autologous mixed leukocyte reaction by sera from patients with systemic lupus erythematosus
نویسندگان
چکیده
منابع مشابه
The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus.
The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in ...
متن کاملInhibition of proliferative and suppressor responses in the autologous mixed lymphocyte reaction by serum from patients with systemic lupus erythematosus.
Serum from patients with systemic lupus erythematosus (SLE) prevents the proliferative response of normal T cells when stimulated by autologous or allogeneic non-T cells. The abrogation of proliferation in an autologous mixed lymphocyte reaction (AMLR) with SLE serum is associated with a lack of suppressor T cell generation. Fractionation of SLE sera on sucrose gradients reveals an 18-12 S peak...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1982
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780250404